I have a horse that has a suppressed immune system due to diagnosed Cushings, and despite medication and the best skin and allergy supplement, he still has terrible breakouts in the summer months with hives and rashes. He suffers also from Anhydrosis, so he cannot wear fly sheets. The Equiderma Lotion is the ONLY product I have found (I have tried them all, including homemade potions) that brings him almost instant relief, takes the swelling out of the lesions when he has an outbreak, and quickly heals him up. It makes his time in the miserable Oklahoma summers almost bearable.