I have adult acne that's mainly hormonal. I've started to learn how to care for my skin and gut microbiome over the years and am glad a product like this exists. It took awhile to feel like the serum definitively had made progress on my skin. (about a month and a half). But even before then I enjoyed being able to bring my skin care routine down to only nourishing products. I use Cetaphil gentle skin cleaner, 1 pump of the phage serum, The Ordinary natural moisturizing factors, and rose hips oil twice a day. To help make the serum spread across my whole face I pump it into my hand, then using my finger dab it all over my face concentrating most of the product on my problem areas, then I rub it all in. I started to take seed probiotics around the same time which probably had a role in my results as well. I do wish Phyla would release a list of unapproved ingredients that they know would harm the phage so it was easier to build a skin routine around the serum. Also, I still get acne it just less frequent, less angry, easier to get rid of, and my skin heals faster. Ill take it!