Squirting in her mouth didnt have much effect. They suggested 'painting it on her gums' or inside ears. She wont let me do her ears & took week or so putting on my finger & rubbing on her upper gums then finally she started letting me squirt from dropper along upper side of gums 2x day & noticed some improvement. She still has leash reactivity & very obsessed with certain ball for fetch. But it has helped some like can redirect or get her attention & lil more relaxed. We also tried the dog cookie version (came as free gift) & they love those & easy dose.