“Our elderly female German Shepard developed incontinence (common with large dogs spayed early). Our vet first put her the estrogen pills... didn't help. Tried the 145 mg Prion tablets, which I crush and mixed with a raw egg to make it easy to administer, and she immediately improved. To be on the safe side, we still diaper the old girl when she comes in at night, but It's quite rare for her to leak before she gets let out in the morning. I'd say the efficacy rate is a solid 95% or better, which our vet says as prescriptions go is considered a win. Am now trying the chewables to see if we can save on eggs. ;-)”