“The use of Prion totally stopped my Great Dane from having bladder releases at night. Many female dogs have a tendency to have this issue after being spayed when young and was at a loss what to do. She is close to 5 years old now. Tried a really nice dog diaper but she was not comfortable and made her anxious and restless. The first day on Prion she did not have a mishap nor more than 3 weeks now. Great product and no side effects. Recommend. Allivet was great to work with insuring I got my vet's prescription in the mail ASAP even overnighting the Prion. Great!!”