My newborn had terrible crying spells where she was inconsolable. We tried evivo out of desperation and the crying greatly and very noticably diminished. The effects were quick. Perhaps it was a coincidence but I'm not taking any chances and will continue to use this. Also when we started evivo she hadn't pooped in about a week. The Dr said that was normal for some babies. But after taking this she pooped a ton and has been regular ever since. Definitely recommend.