I did think Premier Research was PREMIER...however lately I find many variables in products...one of which is the melatonin which varies from bottle to bottle in the SAME shipment. I have addressed this but have not found a response...If you have responded I apologize and would request that you resend that response as it is concerning for me. I have also noted variables with Cardio ND Please note I have been purchasing these supplements for years and until recently have had no problem...But I have noticed it within the last 8-12 months...the other was the tubing for the enema bucket...the new one DOES NOT DRY...EVER! I did get a response to this which was to purchase a brush...this is not addressing the change in the product. The tube ALWAYS dried before...I have had it out for more than 7 days now and still, the tube has not dried...What has been changed in the manufacturing??? is what I want to know.