I have had diarrhea since last Saturday but due for shot last Sunday so I still took shot not knowing if I had the flu or did wrong dose. I still had 20 units in bottle from before I received my new dose so had used that up last Sunday and then took 10 units from new dose to make my 40 units total for last Sunday. But maybe took to much of using the 2 different bottles were mixed differently. My diarrhea is almost gone . The only other thing is I got heartburn this last week but over the counter took care of that, now today. Now today I'm due for next shot. Feel fine.